男性危重患者血清睾酮水平及与APACHEⅡ评分的相关性研究

doi:10.3969/j.issn.1002-1949.2018.09.013

摘要
图/表
参考文献(21)
相关文章 (6)

全文: PDF (431 KB) HTML (1 KB)
输出: BibTeX | EndNote (RIS)

摘要目的探讨重症加强治疗病房（ICU）男性危重患者血清睾酮(TT)水平与急性生理学与慢性健康状况评分系统Ⅱ（APACHEⅡ）评分之间的关系。〖HTH〗方法〓〖HTSS〗选择延安大学附属医院2016-05～2018-03 ICU收治的75例男性危重患者，入ICU后24 h内进行 APACHEⅡ评分，根据分值分为两组：A组＜20分(n=25)和B组≥20分（n=50)，比较TT水平；根据年龄分为两组：C组＜50岁（n=28），D组≥50岁（n=47），比较TT水平；并将TT水平与APACHEⅡ评分进行 Pearson 相关性分析。结果根据APACHEⅡ评分分组，A组TT水平［（5.39±1.83）ng/dL］明显高于B组［(2.68±2.04)ng/dL］， P＜0.01) ；根据年龄分组，两组TT水平比较，差异无统计学意义(P＞0．05)；TT水平与APACHEⅡ评分具有相关性，呈显著负相关(r=-0.70，P=0.00)。结论男性危重患者TT越低，病情越重，与APACHEⅡ评分之间有良好的相关性，对男性危重患者及早监测TT水平对评估病情有一定参考价值。

	服务

	把本文推荐给朋友
	加入我的书架
	加入引用管理器
	E-mail Alert
	RSS
	作者相关文章
	惠智艳
	房阁
	张旭
	袁清霞

关键词 ：危重患者, 血清睾酮(TT), 急性生理学与慢性健康状况评分系统Ⅱ（APACHEⅡ）评分

作者简介: 惠智艳（1985-），女，硕士，主治医师，E-mail:hzy1149@163.com。

引用本文:

惠智艳,房阁,张旭,袁清霞. 男性危重患者血清睾酮水平及与APACHEⅡ评分的相关性研究[J]. 中国急救医学, 2018, 38(9): 803-806.
Hui Zhi-yan, Fang Ge, Zhang Xu, Yuan Qing-xia. Serum total testosterone in male critically ill patients: correlations with APACHE Ⅱ score. Chinese Journal of Critical Care Medicine, 2018, 38(9): 803-806.

链接本文:

http://www.cnemergency.org.cn/CN/10.3969/j.issn.1002-1949.2018.09.013 或 http://www.cnemergency.org.cn/CN/Y2018/V38/I9/803

［1］Luppa P, Munker R, Nagel D, et al. Serum androgens in intensive-care patients: correlations with clinical findings［J］. Clin Endocrinol (Oxf), 1991, 34(4):305-310. ［2］肖军，钟荣，叶桂山. APACHEⅡ、SAPSⅡ及LODS 3种评分系统在单一重症监护室的应用比较［J］.中华危重病急救医学， 2006， 18（12）：743-747.  ［3］刘静波，黄萍. MEWS评分和APACHEⅡ评分对急诊老年危重症患者预后的评估［J］.医学综述， 2013， 19（8）：1491-1493.  ［4］陈洁茹，陈伟燕，熊旭明. APACHEⅡ评分系统在综合ICU中的应用［J］. 广东医学， 2013， 34（1）：86-89.  ［5］Salluh JI， Soares M. ICU severity of illness scores： APACHE， SAPS and MPM［J］. Curr Opin Crit Care， 2014， 20（5）：557-565. ［6］Christeff N, Benassayag C, Carli-Vielle C, et al. Elevated oestrogen and reduced testosterone levels in the serum of male septic shock patients［J］. J Steroid Biochem， 1988， 29(4):435-440. ［7］Schneider HJ, Sievers C, Klotsche J, et al. Prevalence of low male testosterone levels in primary care in Germany: cross-sectional results from the DETECT study［J］. Clin Endocrinol (Oxf)， 2009， 70(3):446-454.  ［8］Fabbri E, An Y, Gonzalez-Freire M, et al. Bioavailable testosterone linearly declines over a wide age spectrum in Men and Women from the baltimore longitudinal study of aging［J］. J Gerontol A Biol Sci Med Sci， 2016， 71(9):1202-1209. ［9］Hsu B, Cumming RG, Naganathan V, et al. Temporal changes in androgens and estrogens are associated with all-cause and cause-specific mortality in older Men［J］. J Clin Endocrinol Metab， 2016， 101(5):2201-2210. ［10］Harman SM, Metter EJ, Tobin JD, et al. Longitudinal effects of aging on serum total and free testosterone levels in healthy men. Baltimore Longitudinal Study of Aging［J］. J Clin Endocrinol Metabo， 2001， 86(2):724-731. ［11］Kaufman JM, Vermeulen A. The decline of androgen levels in elderly men and its clinical and therapeutic implications［J］. Endocr Rev， 2005， 26(6):833-876. ［12］Mellstrm D, Johnell O, Ljunggren O, et al. Free testosterone is an independent predictor of BMD and prevalent fractures in elderly men: MrOS Sweden［J］. J Bone Miner Res， 2006， 21(4):529-535. ［13］Liu Z, Liu J, Shi X, et al. Dynamic alteration of serum testosterone with aging: a cross-sectional study from Shanghai, China［J］. Reprod Biol Endocrinol， 2015， 13(9):111.  ［14］Shen X, Wang R, Yu N, et al. Reference Ranges and Association of Age and Lifestyle Characteristics with Testosterone, Sex Hormone Binding Globulin, and Luteinizing Hormone among 1166 Western Chinese Men［J］. PLoS ONE, 2016， 11(10)：e0164 116.  ［15］Spratt DI, Cox P, Orav J, et al. Reproductive axis suppression in acute illness is related to disease severity［J］. J Clin Endocrinol Metab, 1993， 76(6):1548-1554. ［16］Travison TG, Shackelton R, Araujo AB, et al. The natural history of symptomatic androgen de ciency in men: onset, progression, and spontaneous remission［J］. J Am Geriat Soc， 2008， 56(5):831-839. ［17］Fourrier F, Jallot A, Leclerc L, et al. Sex steroid hormones in circulatory shock, sepsis syndrome, and septic shock［J］. Circ Shock, 1994, 43(4):171-178. ［18］Corona G, Maseroli E, Rastrelli G, et al. Is late-onset hypogonadotropic hypogonadism a specific age-dependent disease, or merely an epiphenomenon caused by accumulating disease-burden［J］. Minerva Endocrinol， 2016， 41(2):196-210. ［19］Corona G, Rastrelli G, Maseroli E, et al. Low testosterone syndrome protects subjects with high cardiovascular risk burden from major adverse cardiovascular events［J］. Andrology， 2014， 2(5): 741-747. ［20］Rochira V, Diazzi C, Santi D, et al. Low testosterone is associated with poor health status in men with human immunodeficiency virus infection: a retrospective study［J］. Andrology, 2015, 3(2): 298-308.  ［21］陆双双，李莹，吴莉莉,等. APACHEⅡ评分系统的应用及进展［J］,东南国防医药, 2015, 7(17):422-425.