非肝病性高血氨在重症患者中值得关注

doi:10.3969/j.issn.1002-1949.2019.04.003

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摘要血氨作为体内氨基酸的主要代谢产物，在物质代谢和生物转化过程中发挥重要作用。现阶段的研究多是针对肝脏疾病导致的高血氨及氨中毒学说，而非肝脏疾病导致血氨增加的原因以及高血氨对于其他脏器功能的影响一直被忽视。无基础肝病（急性肝衰竭或慢性肝病），由其他原因引起的血氨增高被称为非肝病性高血氨（non-hepatic hyperammonemia, NHH），目前NHH尚未引起临床广泛重视。本文将针对重症患者发生NHH的病理生理机制、临床意义以及血氨与疾病的关系进行探讨，希望对相关疾病的临床诊断、病情评估和治疗有所启发。

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	姚志鹏
	王洪亮

关键词 ：非肝病性高血氨（NHH）, 氨基酸代谢, 重症患者, 血氨检测

基金资助:哈尔滨市科技局（2016RAQXJ154）

通讯作者: 王洪亮（1976-），男，博士，主任医师，教授，硕士生导师，E-mail：icuwanghongliang@163.com。

作者简介: 姚志鹏（1990-），男，住院医师，E-mail：yaozhipeng215@163.com。

引用本文:

姚志鹏，王洪亮. 非肝病性高血氨在重症患者中值得关注[J]. 中国急救医学, 2019, 39(4): 313-315.
Yao Zhi-peng, Wang Hong-liang. Attention should be paid to non-hepatic hyperammonemia in severe patients. Chinese Journal of Critical Care Medicine, 2019, 39(4): 313-315.

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http://www.cnemergency.org.cn/CN/10.3969/j.issn.1002-1949.2019.04.003 或 http://www.cnemergency.org.cn/CN/Y2019/V39/I4/313

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