心脏骤停动物模型研究进展

doi:10.3969/j.issn.1002-1949.2018.06.019

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摘要心脏骤停（cardiac arrest，CA）和心肺复苏（CPR）长期以来都是急诊医学中的研究热点。由于CA发生突然，难以进行临床对照试验，因而动物实验不可或缺，建立一种能够最大限度模拟临床的动物CA模型成为亟待解决的问题。目前常用于CA和CPR研究的实验动物大致分为小动物，如大鼠等；中等动物，如家兔等；大动物，如猪、犬等。而就CA诱发方式而言，有电击法、窒息法、钳夹大血管法等。本文就国内外对CPR动物模型的基本要求、种类、制作方法及其特点等予以综述。

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	孙占朋
	廖晓星

关键词 ：心脏骤停(CA), 心肺复苏(CPR), 动物模型, 心室颤动(VF), 自主循环恢复

基金资助:国家自然科学基金（81571865）；广东省科技计划项目（2015A020212008）

通讯作者: 廖晓星(1955-)，男，教授，主任医师，博士，E-mail:liaowens@163.com。

作者简介: 孙占朋（1988-），男，硕士，住院医师，E-mail:1036884459@qq.com。

引用本文:

孙占朋，廖晓星. 心脏骤停动物模型研究进展[J]. 中国急救医学, 2018, 38(6): 548-.
Sun Zhan-peng, Liao Xiao-xing. Research progresses in the animal models of cardiac arrest. Chinese Journal of Critical Care Medicine, 2018, 38(6): 548-.

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http://www.cnemergency.org.cn/CN/10.3969/j.issn.1002-1949.2018.06.019 或 http://www.cnemergency.org.cn/CN/Y2018/V38/I6/548

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