甘油三酯/高密度脂蛋白胆固醇的比值在急性缺血性脑卒中预后价值的研究

doi:10.3969/j.issn.1002-1949.2017.10.012

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摘要目的：探讨甘油三酯（TG）/高密度脂蛋白胆固醇（HDL-C）比值与急性缺血性脑卒中（AIS）患者预后的关系。方法：收集1006例首发AIS住院患者的临床资料。所有患者在入院36 h内分别测定血浆TG、总胆固醇（TC）、HDL-C和低密度脂蛋白胆固醇（LDL-C）的水平。3个月后根据改良Rankin评分量表（mRS）分为两种不同的预后：mRS 0～1预后良好，6即死亡。结果：较高水平TG、非高密度脂蛋白胆固醇(Non-HDL-C)和TG/HDL-C与AIS患者预后密切相关：预后良好的 OR值分别为1.39、1.89 和2.34 ，死亡的OR值分别为0.59、0.29和0.26。TG/HDL-C≥0.87是临床预后良好［ROC曲线下面积(AUC)为0.596，敏感度73.3%，特异度42.7%］和非死亡(AUC 0.674，敏感度 67.8%，特异度60.6%)的最佳区分因子。与TG/HDL-C≥0.87比较，TG/HDL-C＜0.87 时AIS患者死亡风险增加2.94倍。结论：较低的TG/HDL-C比值与AIS患者3个月后死亡和预后不良独立相关。

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	孙才智
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	张铮
	何小卫

收稿日期: 2017-02-18

通讯作者: 何小卫（1977-），男，硕士，副主任医师，E-mail: 188645866@qq.com

作者简介: 孙才智（1987-），男，硕士，E-mail: sczicu@163.com

引用本文:

孙才智，邓齐文，张铮，何小卫. 甘油三酯/高密度脂蛋白胆固醇的比值在急性缺血性脑卒中预后价值的研究[J]. 中国急救医学, 2017, 37(10): 923-928.
Sun Cai-zhi, Deng Qi-wen, Zhang Zheng,He Xiao-wei. Triglyceride to high-density lipoprotein cholesterol ratio predicts worse outcomes after acute ischemic stroke. Chinese Journal of Critical Care Medicine, 2017, 37(10): 923-928.

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http://www.cnemergency.org.cn/CN/10.3969/j.issn.1002-1949.2017.10.012 或 http://www.cnemergency.org.cn/CN/Y2017/V37/I10/923

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