维生素C：脓毒症辅助治疗的选择

doi:10.3969/j.issn.1002-1949.2019.11.021

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摘要脓毒症是宿主对感染反应失调引起危及生命的器官功能障碍，是病理感染与生理变化共同作用的结果，具有发病率高、病死率高、住院花费高等特点，是导致重症患者死亡的主要原因,已成为21世纪全球面临的重要公共卫生难题。其发病机制复杂，至今仍未完全阐明，最新指南仍推荐集束化治疗策略。新近有研究显示，大剂量维生素C可降低脓毒症病死率，本综述目的是阐述维生素C对脓毒症的有益作用和可能机制，以期为脓毒症研究和治疗提供帮助。

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	李小燕
	李培杰

关键词 ：脓毒症, 维生素C(VitC), 炎症, 氧化应激

通讯作者: 李培杰（1962-），男，教授，主任医师，重症医学科主任，硕士生导师，E-mail：lipeijielanzhou@hotmail.com。

作者简介: 李小燕（1989-），女，硕士研究生，E-mail：lixy17@lzu.edu.cn。

引用本文:

李小燕，李培杰. 维生素C：脓毒症辅助治疗的选择[J]. 中国急救医学, 2019, 39(11): 1110-1114.
Li Xiao-yan, Li Pei-jie. Vitamin C: a choice of adjuvant treatment for sepsis. Chinese Journal of Critical Care Medicine, 2019, 39(11): 1110-1114.

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http://www.cnemergency.org.cn/CN/10.3969/j.issn.1002-1949.2019.11.021 或 http://www.cnemergency.org.cn/CN/Y2019/V39/I11/1110

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