MAPK信号转导通路与失血性休克相关性的研究进展

doi:10.3969/j.issn.1002-1949.2018.08.009

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摘要丝裂原活化蛋白激酶(MAPKs)信号转导通路家族在受到生长因子、细胞因子、神经递质、激素等多种信号分子刺激后发生磷酸化而活化，活化后的MAPKs可参与应激反应、细胞增殖、分化及介导炎症反应和器官损伤等病理生理过程。失血性休克的病理生理改变不仅有血液动力学部分，还有炎症反应部分及休克后缺血/再灌注所致的器官损伤。对失血性休克的治疗不仅仅满足于控制出血及液体复苏恢复组织灌注，同时还应关注其炎症反应，预防多器官功能障碍。随着对创伤及失血性休克与MAPK通路研究的进行，MAPK信号通路与失血性休克的关系进一步明确，更多以该条通路为靶点的药物研发将得到更好的理论支持。本文就MAPK信号通路与失血性休克所致器官损伤、炎症反应等相关性及临床应用前景进行简要综述。

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	宋琦
	王振杰

关键词 ： MAPK信号转导通路, 失血性休克, 炎症反应, 器官损伤, 丝裂原活化蛋白激酶(MAPKs)

基金资助:安徽省科技计划攻关项目(1604a0802089)

通讯作者: 王振杰（1963-），男，教授，主任医师，博士生导师，E-mail:ahbyfywzj@163.com。

作者简介: 宋琦（1991-），男，硕士研究生，E-mail:732803847@qq.com。

引用本文:

宋琦，王振杰. MAPK信号转导通路与失血性休克相关性的研究进展[J]. 中国急救医学, 2018, 38(8): 684-689.
Song Qi, Wang Zhen-jie. Progress of relationship between MAPK signal transduction pathway and hemorrhagic shock. Chinese Journal of Critical Care Medicine, 2018, 38(8): 684-689.

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http://www.cnemergency.org.cn/CN/10.3969/j.issn.1002-1949.2018.08.009 或 http://www.cnemergency.org.cn/CN/Y2018/V38/I8/684

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