脓毒症并发急性呼吸窘迫综合征的治疗策略

doi:10.3969/j.issn.1002-1949.2017.10.003

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摘要脓毒症（sepsis）具有很高的发病率和病死率，据统计，全世界每天大约有1.5万例患者死于此病及其并发症。肺脏是最易受损的器官之一，研究资料显示，超过40%的脓毒症患者并发急性肺损伤/急性呼吸窘迫综合征（ALI/ARDS），病死率高达30%~40%。脓毒症一旦合并ALI/ARDS可加重疾病的演变过程，增加多脏器衰竭及死亡风险。因此，探讨脓毒症ARDS的机制，积极寻求其治疗策略尤为重要。其治疗主要包含呼吸支持、体外膜肺、抗炎、抗凝血、血管活性药物、液体管理及干细胞治疗等策略。本文对脓毒症并发ARDS近期的相关治疗策略进行综述，进一步阐明脓毒症ARDS的发病机制和病理生理，寻找新的治疗靶点和方向。

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	章梦丽
	李文强

收稿日期: 2017-05-16

基金资助:湖北省自然科学基金（2012FKB04445）

通讯作者: 李文强（1967-），男，博士，主任医师，副教授，急诊科副主任，E-mail:13971583642@139.com

作者简介: 章梦丽（1991-），女，硕士研究生， E-mail:18772848521@163.com

引用本文:

章梦丽，李文强. 脓毒症并发急性呼吸窘迫综合征的治疗策略[J]. 中国急救医学, 2017, 37(10): 883-888.
Zhang Meng-li, Li Wen-qiang. Treatment strategy of sepsis complicated with acute respiratory distress syndrome. Chinese Journal of Critical Care Medicine, 2017, 37(10): 883-888.

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http://www.cnemergency.org.cn/CN/10.3969/j.issn.1002-1949.2017.10.003 或 http://www.cnemergency.org.cn/CN/Y2017/V37/I10/883

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